Moreover, blood chemistry tests were performed to evaluate renal function, cardiac biomarkers, fT3, fT4, and TSH levels.

Methods: From the extensive analysis of PPIs between Yersinia pestis bacteria and humans, we recently discovered an interesting relation; a linear relation between amino acid composition and sequence length was observed in many proteins involved in PPIs.

Conclusion: The feature types identified in our study are simple yet powerful in predicting pathogen-human PPIs.

With an improved understanding of the complex interactions between breast cancer and the immune system, immunotherapy has shown great potential in clinical management, potentially adding to current treatment modalities.

These immunotherapeutic approaches include adoptive cell transfer therapy, cancer vaccination, monoclonal antibody therapy, and oncolytic virus therapy.

Depending on the immune cells and cytokines present, the tumour microenvironment (TME) can be immunosuppressive or favourable for mounting an immune response.

Many studies have made good progress in the modulation of the immune response to allow the identification and elimination of tumour cells.

However, the efficacy of these immunotherapies is patient-specific and highly dependent on the immunological profile of the tumour and its TME.

This review will give an overview of breast cancer, the immune system as well as their complex relationship.

School of Medicine, University of Bari, Piazza Giulio Cesare 11, Policlinico of Bari, Bari, Apulia, Italy.

Aim: The aim of the study was to evaluate the impact of TSH changes over time on cardiac function and prognosis of outpatients with CHF.

Methods: Patients underwent clinical, electrocardiographic, and echocardiographic evaluations at baseline and after 12 months.

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